Congratulations to Dr. Loughrey on successfully defending his PhD work! David joined the Lucks lab after completing his B.S. in Chemical Engineering at University College Dublin and has been instrumental in helping the lab develop next generation techniques for RNA structure determination. Check out David’s publication on SHAPE-Seq 2.0 here! […]
We are seeking a creative and enthusiastic postdoctoral researcher to lead a project to map nascent RNA structure as part of multiple efforts sponsored by the NIH. Recently our laboratory created co- transcriptional SHAPE-Seq which uses chemical probing and next-generation sequencing to map the structure of nascent RNAs at single-nucleotide […]
Julius and James recently shared with Benchling, a life science data management and collaboration platform, the conceptual design and implementation of small transcription activating RNAs (STARs). The minisite details how terminator structures in biology are used to halt transcription and how they can be cleverly reconfigured to attenuate or activate […]
Julius and Khalid recently attended the inaugural retreat of the Engineering Biology Research Consortium (EBRC) held at Caltech. EBRC (https://www.ebrc.org) aims to be the leading organization in the field of synthetic biology, showcasing cutting-edge research, identifying and addressing global challenges in the field, and building an inclusive community of students, […]
Congratulations to the iGEM team at Imperial College who managed to win the Grand Prize at this years iGEM competition for their “ecolibrium” project that we recently featured on our website. @imperialigem wins the Grand Prize at #iGEM2016 #GiantJamboree! Congratulations! You guys are some real STARs! https://t.co/4i9ayYM3Nh — The Lucks […]
Kyle, Eric, and Angela’s paper “Cotranscriptional Folding of a Riboswitch at Nucleotide Resolution” is online in Nature Structural and Molecular Biology and a featured news story through Northwestern. With the development of cotranscriptional SHAPE-seq, this paper marks a milestone in RNA biology as the first strategy for the measurement of nascent RNA […]
In the weeks before officially moving to the Chicagoland area, the Lucks Lab attended the 2016 SEED (Synthetic Biology: Engineering, Evolution & Design) conference, held in the historic Hilton Chicago. As part of receiving the ACS Synthetic Biology Young Investigator Award, Julius presented a research seminar on the groups latest […]
Congratulations to the Imperial College London 2016 iGEM team for using Small Transcription Activating RNAs (STARs) regulators in their project – ecolibrium! Their project looks at developing a framework and new tools for engineering co-cultures of bacteria. We’re honored that they choose to use STARs and the power of RNA […]
Eric and Julius recently attended the 18th Annual Rustbelt RNA Meeting in Cleveland. Eric had the opportunity to present a short talk on his latest work on SHAPE-Seq technology and was later presented with the award for best talk! Congratulations Eric!
The entire Lucks Lab for RNA Engineering has recently moved to Northwestern University! The lab joins the Department of Chemical and Biological Engineering in the McCormick School of Engineering and joins Danielle Tullman Ercek’s group as the newest members of Northwestern’s Center for Synthetic Biology, which aims to program biological […]
The Lucks Lab for RNA Engineering is excited to announce that Khalid K. Alam has joined the lab as the newest postdoctoral fellow! Khalid recently completed his PhD work on aptamer evolution and engineering from the Burke Lab at the University of Missouri, and supplements the Lucks Lab’s expertise […]
Julius was named the recipient of the 2016 ACS Synthetic Biology Young Investigator Award. Established in 2014, the award recognizes the contribution of a scientist who has made a major impact on the field of synthetic biology, early in their career. Julius was presented with the award and gave a […]
Katherine and Matthew have joined the lab from the Biochemistry, Molecular and Cellular Biology program – welcome Katherine and Mathew!
Anyone that has spent any time with us knows how much we love Trello. If you haven’t heard of it, it is a lightweight team management tool that we use throughout the lab – from writing papers and grants, to managing lab orders and our lab safety system. We’ve even […]
Dr. Watters next heads to Jennifer Doudna’s lab – go Dr. Watters!
Kyle is the recipient of an Austin Hooey Graduate Award. The Hooey award is the highest honor that CBE bestows on graduate students, and recognizes those students who have demonstrated the highest research quality and productivity, and who have demonstrated a track record of service to their research group, department, and community. […]
Congratulations Alex for winning the CBE 2016 Outstanding Scholar Award! The award recognizes Alex’s outstanding research accomplishments as an undergraduate and his transition to industry where he will join Caribou Biosciences. Congratulations Alex!
Melissa, Kyle, Tim and Paul’s paper “Using in-cell SHAPE-Seq and simulations to probe structure-function design principles of RNA transcriptional regulators” is out in RNA! This paper marks an important milestone for us – its our first manuscript on using information gleaned from in-cell SHAPE-Seq experiments to inform the design of new […]
Spats v1.0.0 is an update to the Spats pipeline for processing Next-Generation Sequencing Reads as part of SHAPE-Seq experiments. The major difference between v0.8.0 and v1.0.0 is the migration to the cutadapt utility for removing adapter sequences from the fastxtoolkit. This release still relies on fastx_revcomp, but the code is structured […]
Kyle, Angela, Eric and Alex’s paper “Characterizing RNA structures in vitro and in vivo with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)” is out in Methods! This is a very comprehensive manuscript, outlining the necessary background for understanding chemical probing of RNA structure – from the experiments that can […]
Eric, Kyle and David’s review “RNA systems biology: uniting functional discoveries and structural tools to understand global roles of RNAs” is out in Current Opinion in Biotechnology! In this review, we outline the case that the time is right for a systems-level study of RNA structure and function – partly […]
Cameron’s review “Engineered Protein Machines: Emergent Tools for Synthetic Biology” is out in the inaugural edition of Cell Chemical Biology! This is a great summary of recent work in synthetic biology to make ‘orthogonal’ versions of core cellular protein machines – from polymerases all the way to ribosomes. By acting […]