Jeff Tabor, a rising star in synthetic biology now at Rice wrote an excellent news and views article about our recent Nature Methods paper on engineering RNA transcriptional regulators. This is a particularly exciting paper led by Chang Liu in the Arkin Lab (soon to be at UC Irvine) where we were able to convert RNA-based translation regulation into transcription regulation by first feeding it through a classic leader-peptide transcriptional attenuator. This is also a great example of how experimental RNA structure analysis can lead to insights and design principles for engineering RNAs.
Tabor does an excellent job of placing our work in the context of the larger goal of creating programmable genetic circuitry inside cells, and makes a convincing case for RNA synthetic biology! Click here for the full news and views article.