James and Julius were recently asked to write a preview on a new paper published in Cell Systems (“Design and Construction of Generalizable RNA-Protein Hybrid Controllers by Level-Matched Genetic Signal Amplification”). Read their preview, “Turning It Up to 11: Modular Proteins Amplify RNA Sensors for Sophisticated Circuitry,” on how ligand-sensing RNA switches can be enhanced using protein-based amplifiers to deliver sophisticated signal-processing genetic circuitry here.